Abstract | OBJECTIVE: The aim of this study was to determine the expression of N-Glycolyl GM3 (NeuGcGM3) ganglioside in oral mucosal melanomas. MATERIALS AND METHODS: RESULTS: We first checked the expression of CMAH in ME and two fresh oral mucosal melanoma tissues. Presence of NeuGcGM3 ganglioside was evident in 37 of 44 cases (84.1%), showing a diffuse cytoplasmic and membranous staining. Patients with primary occurrence showed high levels of NeuGcGM3 ganglioside compared to patients with secondary occurrence. On the other hand, negative immunoreaction was evidenced in oral melanotic nevi. ME also presented the expression of NeuGcGM3 by immunocytochemistry. CONCLUSIONS: In this work, we for the first time evaluated the expression of 14F7 MAb immunorecognition in oral mucosal melanomas. Our results were in agreement with the assumption that NeuGcGM3 ganglioside may be considered as target for passive and active immunotherapy in oral mucosal melanomas expressing this molecule and indicate less risk of recurrence and a better prognosis. Moreover, ME provides a platform for more studies on the specific function of NeuGcGM3 in oral mucosal melanomas.
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Authors | Y Zhong, Y Wu, C Li, J Tang, X Wang, G Ren, A Carr, R Pérez, W Guo |
Journal | Oral diseases
(Oral Dis)
Vol. 18
Issue 8
Pg. 741-7
(Nov 2012)
ISSN: 1601-0825 [Electronic] Denmark |
PMID | 22574836
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
- Antibodies, Monoclonal
- G(M3) Ganglioside
- Immunoglobulin G
- N-glycolylneuraminyllactosylceramide
- Mixed Function Oxygenases
- CMPacetylneuraminate monooxygenase
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Topics |
- Antibodies, Monoclonal
- Cell Line, Tumor
- Cell Membrane
(ultrastructure)
- China
- Cytoplasm
(ultrastructure)
- Female
- G(M3) Ganglioside
(analogs & derivatives, analysis, immunology)
- Humans
- Immunoglobulin G
- Immunohistochemistry
- Male
- Melanoma
(pathology, secondary)
- Middle Aged
- Mixed Function Oxygenases
(analysis)
- Mouth Mucosa
(pathology)
- Mouth Neoplasms
(pathology)
- Neoplasm Recurrence, Local
(pathology)
- Nevus, Pigmented
(pathology)
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