Abstract |
Purpose. The objective of this study was to compare the salivary protein profiles from individuals diagnosed with breast cancer that were either HER2/ neu receptor positive or negative. Methods. Two pooled saliva specimens underwent proteomic analysis. One pooled specimen was from women diagnosed with stage IIa HER2/ neu-receptor-positive breast cancer patients (n = 10) and the other was from women diagnosed with stage IIa HER2/ neu-receptor-negative cancer patients (n = 10). The pooled samples were trypsinized and the peptides labeled with iTRAQ reagent. Specimens were analyzed using an LC-MS/MS mass spectrometer. Results. The results yielded approximately 71 differentially expressed proteins in the saliva specimens. There were 34 upregulated proteins and 37 downregulated proteins.
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Authors | Charles F Streckfus, Daniel Arreola, Cynthia Edwards, Lenora Bigler |
Journal | Journal of oncology
(J Oncol)
Vol. 2012
Pg. 413256
( 2012)
ISSN: 1687-8469 [Electronic] Egypt |
PMID | 22570650
(Publication Type: Journal Article)
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