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Correlation between histological subtypes and MRI findings in clinically nonfunctioning pituitary adenomas.

Abstract
Clinically nonfunctioning pituitary adenomas (CNFPAs) consist of several histological subtypes, including null cell adenoma (NCA), silent gonadotroph cell adenoma (SGA), silent corticotroph adenoma (SCA), and other silent adenomas (OSA) (i.e., GH, TSH, and prolactin adenomas). To detect possible correlations between MRI findings and the subtypes, we retrospectively studied 390 consecutive patients with CNFPA who underwent surgery between 2008 and 2010. They were classified into three groups: NCA/SGA (313 cases), SCA (39 cases), and OSA (36 cases); in addition there were two unusual cases of plurihormonal adenoma. Three MRI findings were less common in NCA/SGA than in the other groups (P < 0.0001): giant adenoma (>40 mm), marked cavernous sinus invasion (Knosp grade 4), and lobulated configuration of the suprasellar tumor. When these MRI findings were negative in patients older than 40 years old, 91.0% (212/233) were NCA/SGA. These MRI findings were frequently noted despite a low MIB-1 index in SCA. OSA showed a high MIB-1 index and a preponderance in younger patients. In conclusion, although SCA and OSA consisted of only 20% of CNFPAs, their frequency significantly increased when the tumor was large, invasive, and lobulated, and the patient was younger than 40 years old.
AuthorsHiroshi Nishioka, Naoko Inoshita, Toshiaki Sano, Noriaki Fukuhara, Shozo Yamada
JournalEndocrine pathology (Endocr Pathol) Vol. 23 Issue 3 Pg. 151-6 (Sep 2012) ISSN: 1559-0097 [Electronic] United States
PMID22569896 (Publication Type: Journal Article)
Chemical References
  • Ki-67 Antigen
Topics
  • Adenoma (classification, pathology)
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Humans
  • Immunohistochemistry
  • Ki-67 Antigen (analysis)
  • Lymphocytes, Null (pathology)
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Pituitary Neoplasms (classification, pathology)
  • Retrospective Studies

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