Evaluation of antioxidant and immunity function of tetramethylpyrazine phosphate tablets in vivo.

Abstract	The aim of the study was to determine the effect of tetramethylpyrazine phosphate tablets (TPT), a Chinese medicine used for cardiovascular disease, on immunity activity and oxidative injury in rats. Heart failure (HF) was induced by isoproterenol (ISO). After the animal model was established, the rats were administered the TPT by gavage (once a day). The results indicated that TPT improved left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), ±dP/dt, heart weight/body weight. TPT could decrease the levels of tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6). Furthermore, it also could raise the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), but reduce malonyldialdehyde (MDA) level. The results indicated that TPT improved cardiac function and myocardial fibrosis from myocardial injury, and this cardioprotection might be attributed to a reduction of oxidative stress and regulation of inflammation mediators.
Authors	Ling Guo, Aihong Wang, Yongle Sun, Chongen Xu
Journal	Molecules (Basel, Switzerland) (Molecules) Vol. 17 Issue 5 Pg. 5412-21 (May 08 2012) ISSN: 1420-3049 [Electronic] Switzerland
PMID	22569420 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antioxidants Cardiotonic Agents Interleukin-6 Organophosphates Pyrazines Tablets Tumor Necrosis Factor-alpha Malondialdehyde Catalase Glutathione Peroxidase Superoxide Dismutase Isoproterenol tetramethylpyrazine
Topics	Animals Antioxidants (therapeutic use) Blood Pressure (drug effects) Body Weight (drug effects) Cardiotonic Agents (therapeutic use) Catalase (metabolism) Glutathione Peroxidase (metabolism) Heart (drug effects, physiopathology) Heart Failure (chemically induced, drug therapy, immunology, metabolism) Interleukin-6 (biosynthesis, immunology) Isoproterenol Malondialdehyde (analysis) Organ Size (drug effects) Organophosphates (therapeutic use) Oxidative Stress (drug effects) Pyrazines (therapeutic use) Rats Rats, Wistar Superoxide Dismutase (metabolism) Tablets Tumor Necrosis Factor-alpha (biosynthesis, immunology) Ventricular Function, Left (drug effects)

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