Abstract | OBJECTIVE: MATERIAL AND METHODS: Forty subjects with initial peri-implantitis, i.e. pocket probing depths ( PPD) 4-6 mm with concomitant bleeding on probing (BoP) and marginal bone loss ranging from 0.5 to 2 mm between delivery of the reconstruction and pre-screening appointment were randomly assigned to two treatment groups. All implants underwent mechanical debridement with titanium curettes, followed by a glycine-based powder airpolishing. Implants in the test group (n = 20) received adjunctive PDT, whereas minocycline microspheres were locally delivered into the peri-implant pockets of control implants (n = 20). At sites with residual BoP, treatment was repeated after 3 and 6 months. The primary outcome variable was the change in the number of sites with BoP. Secondary outcome variables were changes in PPD, in clinical attachment level (CAL), and in mucosal recession (REC). RESULTS: After 3 months, implants of both groups yielded a statistically significant reduction (P < 0.0001) in the number of BoP-positive sites compared with baseline (LDD: from 4.41 ± 1.47 to 2.20 ± 1.28, PDT: from 4.03 ± 1.66 to 2.26 ± 1.28). After 6 months, complete resolution of mucosal inflammation was obtained in 15% of the implants in the control group and in 30% of the implants in the test group (P = 0.16). After 3 months, changes in PPD, REC, and modified Plaque Index (mPlI) were statistically significantly different from baseline (P < 0.05). No statistically significant changes (P > 0.05) occurred between 3 and 6 months. CAL measurements did not yield statistically significant changes (P > 0.05) in both groups during the 6-month observation time. Between-group comparisons revealed no statistically significant differences (P > 0.05) at baseline, 3 and 6 months with the exception of the mPlI after 6 months. CONCLUSIONS:
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Authors | Dorothee Schär, Christoph A Ramseier, Sigrun Eick, Nicole B Arweiler, Anton Sculean, Giovanni E Salvi |
Journal | Clinical oral implants research
(Clin Oral Implants Res)
Vol. 24
Issue 1
Pg. 104-10
(Jan 2013)
ISSN: 1600-0501 [Electronic] Denmark |
PMID | 22568744
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | © 2012 John Wiley & Sons A/S. |
Chemical References |
- Anti-Bacterial Agents
- Minocycline
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Topics |
- Adult
- Aged
- Anti-Bacterial Agents
(administration & dosage)
- Debridement
- Dental Plaque Index
- Female
- Humans
- Male
- Microspheres
- Middle Aged
- Minocycline
(administration & dosage)
- Peri-Implantitis
(drug therapy)
- Periodontal Index
- Photochemotherapy
(methods)
- Prospective Studies
- Treatment Outcome
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