Abstract | BACKGROUND: MATERIALS: The examined materials were obtained from 3 patients who had undergone surgery for plagiocephaly. The sections were obtained from the normal patent side and the abnormal fused side of the coronal suture. The subjects included 2 girls and 1 boy with ages ranging from 1 to 4 years. Osteoblasts and connective tissue were observed with hematoxylin and eosin stain. Immunohistochemistry of the TGF-β isoforms was performed to investigate the difference between the patent and fused sutures. RESULTS: No connective tissue was observed in the fused suture. The osteoblasts in the patent suture were activated, whereas the osteoblasts in the fused suture were inactivated. The osteoblasts were positive for TGF-β1, -β2, and -β3. The periosteum tended to be positive for TGF-β2 and negative for TGF-β1 and -β3. There was no distinct difference between the patent and fused sutures in this study. DISCUSSION: In this study, all sutures had fused completely, and therefore, we may have missed the period when there are differences in protein manifestation. The modulation of the growth factor profile at the suture site may have a potential therapeutic value.
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Authors | Akiko Ueda, Azusa Shimizu, Yuhei Natori, Hiroshi Sonoue, Yuzo Komuro, Masakazu Miyajima, Hajime Arai |
Journal | The Journal of craniofacial surgery
(J Craniofac Surg)
Vol. 23
Issue 3
Pg. 755-7
(May 2012)
ISSN: 1536-3732 [Electronic] United States |
PMID | 22565893
(Publication Type: Journal Article)
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Chemical References |
- Transforming Growth Factor beta1
- Transforming Growth Factor beta2
- Transforming Growth Factor beta3
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Topics |
- Child, Preschool
- Cranial Sutures
(metabolism)
- Female
- Humans
- Infant
- Male
- Plagiocephaly
(surgery)
- Transforming Growth Factor beta1
(metabolism)
- Transforming Growth Factor beta2
(metabolism)
- Transforming Growth Factor beta3
(metabolism)
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