Intervention of TLR4 signal pathway cytokines in severe liver injury with obstructive jaundice in rats.

Abstract

Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice.

• Authors: L Lin, W M Cai, C J Qin, L C Miao, L T Yun, Y Hua, L Weilin
• Journal: International journal of sports medicine (Int J Sports Med) Vol. 33 Issue 7 Pg. 572-9 (Jul 2012) ISSN: 1439-3964 [Electronic] Germany
• PMID: 22562737 (Publication Type: Journal Article)
• Copyright: © Georg Thieme Verlag KG Stuttgart · New York.

Chemical References

• Cytokines
• Plant Extracts
• Tlr4 protein, rat
• Toll-Like Receptor 4

Topics

• Animals
• Bupleurum (chemistry)
• Combined Modality Therapy
• Cytokines (metabolism)
• Disease Models, Animal
• Inflammation (physiopathology, therapy)
• Jaundice, Obstructive (physiopathology, therapy)
• Liver Diseases (physiopathology, therapy)
• Male
• Physical Conditioning, Animal (methods)
• Plant Extracts (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Severity of Illness Index
• Signal Transduction
• Toll-Like Receptor 4 (metabolism)