Monitoring of tumor response to cisplatin by subsurface fluorescence molecular tomography.

Abstract

Subsurface fluorescence molecular tomography (FMT) has promising potential for noninvasive characterization of molecular and cellular activities in small animals by tomographic means in reflectance geometry. In this work, subsurface FMT is employed to monitor the therapeutic response of cisplatin in tumor-bearing mice in vivo. The localization and quantification accuracy of subsurface FMT are demonstrated in phantom. In the in vivo study, the red fluorescent protein activities not only on the surface but in the interior tumor are tracked three-dimensionally during the antitumor treatment.

• Authors: Fei Liu, Xu Cao, Wei He, Jinping Song, Zhongquan Dai, Bin Zhang, Jianwen Luo, Yinghui Li, Jing Bai
• Journal: Journal of biomedical optics (J Biomed Opt) Vol. 17 Issue 4 Pg. 040504 (Apr 2012) ISSN: 1560-2281 [Electronic] United States
• PMID: 22559670 (Publication Type: Letter, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Cisplatin

Topics

• Algorithms
• Animals
• Antineoplastic Agents (pharmacology)
• Cisplatin (pharmacology)
• Drug Monitoring (methods)
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Molecular Imaging (methods)
• Phantoms, Imaging
• Spectrometry, Fluorescence (methods)
• Tomography (methods)
• Whole Body Imaging (methods)
• Xenograft Model Antitumor Assays