Determination of antioxidant status of pre-eclamptic and normotensive sub-rural Nigerian pregnant women at the Irrua Specialist Teaching Hospital, Irrua, Edo State.

Abstract

OBJECTIVES:

To determine the antioxidant levels of subrural Nigerian population where pre-eclampsia and eclampsia is the leading cause of maternal mortality.

METHODS:

Prospective case control study done at Department of Obstetrics and Gynaecology, Irrua Specialist Teaching Hospital Irrua, Edo State, Nigeria. Plasma level of vitamin C and E were evaluated in 80 pre-eclamptic patientswhich were compared with normotensive 80 pregnant women matched as controls.

RESULTS:

Pre-eclampsia was associated with significant reduction in levels of vitamin C and E (p < 0.05). However, the correlation between the blood pressure (severity) and reduction in antioxidants level was not statistically significant.

CONCLUSION:

Pre-eclampsia at Irrua in Nigeria is associated with significant reduction in plasma antioxidants level similar to some reports from the other parts of the world.

• Authors: M A Ikpen, J Eigbefoh, R A Eifediyi, P A Isabu, S Okogbenin, F O Okogbo, M Momoh, K C Ekwedigwe
• Journal: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians (J Matern Fetal Neonatal Med) Vol. 25 Issue 10 Pg. 2046-50 (Oct 2012) ISSN: 1476-4954 [Electronic] England
• PMID: 22551196 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Biomarkers
• Vitamin E
• Ascorbic Acid

Topics

• Adolescent
• Adult
• Antioxidants (metabolism)
• Ascorbic Acid (blood)
• Ascorbic Acid Deficiency (blood, complications)
• Biomarkers (blood)
• Case-Control Studies
• Female
• Hospitals, Teaching
• Humans
• Nigeria
• Pre-Eclampsia (blood, etiology)
• Pregnancy
• Prospective Studies
• Vitamin E (blood)
• Vitamin E Deficiency (blood, complications)
• Young Adult