High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk Hodgkin's lymphoma.

Abstract

BACKGROUND:

Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on thiotepa, etoposide and carboplatin (TECA).

METHODS:

Fifty-eight patients with advanced HL were treated with thiotepa, etoposide and carboplatin for transplant induction.

RESULTS:

The overall response rate was 79·3% (39 CR: 67·2%; and 7 PR: 12·1%); 12 patients (20·1%) were non-responders. The 5-year overall survival rate was 77·6%; five initially responder patients relapsed within the first 5 years of follow-up and underwent salvage therapy.

CONCLUSION:

The TECA conditioning regimen for ASCT in HL results in a good anti-HL effect, positive response to treatment and high 5-year overall survival rate. It was also well tolerated and did not induce excessive toxicity, suggesting that TECA may be a very useful conditioning regimen for HL.

• Authors: Mauro Di Ianni, Stelvio Ballanti, Giuseppe Iodice, Antonia Reale, Franca Falzetti, Olivia Minelli, Gabriella Serio, Massimo F Martelli, Franco Dammacco, Angelo Vacca, Roberto Ria
• Journal: Hematology (Amsterdam, Netherlands) (Hematology) Vol. 17 Issue 1 Pg. 23-7 (Jan 2012) ISSN: 1607-8454 [Electronic] England
• PMID: 22549444 (Publication Type: Clinical Trial, Clinical Trial, Phase II, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bleomycin
• Vinblastine
• Etoposide
• Dacarbazine
• Doxorubicin
• Thiotepa
• Carboplatin

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Bleomycin (administration & dosage)
• Carboplatin (administration & dosage)
• Dacarbazine (administration & dosage)
• Disease-Free Survival
• Doxorubicin (administration & dosage)
• Etoposide (administration & dosage)
• Hematopoietic Stem Cell Transplantation (methods)
• Hodgkin Disease (drug therapy, surgery)
• Humans
• Kaplan-Meier Estimate
• Middle Aged
• Survival Rate
• Thiotepa (administration & dosage)
• Transplantation Conditioning (methods)
• Transplantation, Autologous
• Treatment Outcome
• Vinblastine (administration & dosage)
• Young Adult