Abstract | UNLABELLED: STUDY DESIGN: In vitro cell culture experiments. METHODS: RESULTS: This study demonstrated that intracellular and mitochondrial CoQ10 concentrations increased substantially as higher exogenous concentrations were administered to breast cancer cells. CoQ10 had no effect on the ability of doxorubicin to induce apoptosis or inhibit growth or colony formation in both the cell lines tested when applied over a wide dose range, which encompassed typical basal plasma levels and plasma levels above those typically achieved by supplemented patients. CONCLUSION:
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Authors | Heather Greenlee, Jacquelyn Shaw, Ying-Ka Ingar Lau, Ali Naini, Matthew Maurer |
Journal | Integrative cancer therapies
(Integr Cancer Ther)
Vol. 11
Issue 3
Pg. 243-50
(Sep 2012)
ISSN: 1552-695X [Electronic] United States |
PMID | 22544232
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Antioxidants
- Ubiquinone
- Doxorubicin
- coenzyme Q10
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Topics |
- Antibiotics, Antineoplastic
(adverse effects, pharmacology)
- Antioxidants
(administration & dosage, pharmacokinetics, pharmacology)
- Apoptosis
(drug effects)
- Breast Neoplasms
(drug therapy, pathology)
- Cell Line, Tumor
- Chromatography, High Pressure Liquid
- Dose-Response Relationship, Drug
- Doxorubicin
(adverse effects, pharmacology)
- Drug Interactions
- Female
- Humans
- Mitochondria
(metabolism)
- Ubiquinone
(administration & dosage, analogs & derivatives, pharmacokinetics, pharmacology)
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