Abstract |
Apoptosis has been considered to be involved in schizophrenia. Water channels are modulated just before apoptosis. In the aquaporin family, aquaporin 4 (AQP-4) is most highly expressed in the brain and is supposed to play an important role in a neuronal environment. In this clinical study, we investigated the relationship between the AQP-4 polymorphism and drug response in schizophrenia under the control of the MAOA ( monoamine oxidase A) promoter gene. We recruited 91 patients with schizophrenia, and they were randomized to receive olanzapine (n = 44), risperidone (n = 23), or paliperidone (n = 24). Genotyping of AQP-4 and MAOA polymorphisms was done in all patients. Patients with the AQP-4 non-C polymorphism needed a higher dosage of olanzapine for treatment (z = 4.163, P = 0.041), and patients with a short form of the MAOA polymorphism needed a higher dosage of risperidone for treatment (z = 5.124, P = 0.024). Patients who smoked cigarettes needed a higher dosage of olanzapine for treatment (z = 4.905, P = 0.027), but cigarette smoking did not affect the dosage of paliperidone. The AQP-4 polymorphism may have an effect in influencing the dosage of olanzapine. However, the roles of AQP-4 polymorphisms in the blood-brain barrier and different neuroprotective effects need further exploration in future studies.
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Authors | Ting-Sheng Chung, For-Wey Lung |
Journal | Journal of clinical psychopharmacology
(J Clin Psychopharmacol)
Vol. 32
Issue 3
Pg. 394-7
(Jun 2012)
ISSN: 1533-712X [Electronic] United States |
PMID | 22544010
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- AQP4 protein, human
- Antipsychotic Agents
- Aquaporin 4
- Isoxazoles
- Pyrimidines
- Benzodiazepines
- Monoamine Oxidase
- Risperidone
- Olanzapine
- Paliperidone Palmitate
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Topics |
- Adult
- Antipsychotic Agents
(administration & dosage, therapeutic use)
- Aquaporin 4
(genetics, metabolism)
- Benzodiazepines
(administration & dosage, therapeutic use)
- Diagnostic and Statistical Manual of Mental Disorders
- Drug Monitoring
- Female
- Genetic Association Studies
- Humans
- Isoxazoles
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Monoamine Oxidase
(genetics, metabolism)
- Olanzapine
- Paliperidone Palmitate
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Psychiatric Status Rating Scales
- Pyrimidines
(administration & dosage, therapeutic use)
- Risperidone
(administration & dosage, therapeutic use)
- Schizophrenia
(drug therapy, genetics, metabolism)
- Smoking
(metabolism)
- Young Adult
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