Abstract |
One of the issues of antibiotic treatment is to warrant its optimal effectiveness while minimizing the risk for emergence of resistance. The time above minimal inhibiting concentration (MIC) (T>MIC) is the best predictive pharmacological parameter of effectiveness for antibiotics with time-dependent activity, such as cloxacillin. Cloxacillin is the first line antibiotic in a great number of clinical situations generated by methicillin sensitive staphylococci, because of its intrinsic properties: bactericidal effect, tissue distribution and safety. The most recent anti-staphylococcal agents do not improve treatment of MSSA infections compared to penicillin M and especially cloxacillin. Cloxacillin has a narrow microbiological spectrum. This ecological feature is in line with the recommendation to use antibiotics with the narrowest spectrum to reduce the pressure of selection. The consensus is to have T>MIC for at least 40% of the dosing interval and is achieved by infusing 2g of cloxacillin per day (T>MIC=50%) or four infusions of 3g per day (T>MIC=42%) in adults.
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Authors | J P Bru, R Garraffo |
Journal | Medecine et maladies infectieuses
(Med Mal Infect)
Vol. 42
Issue 6
Pg. 241-6
(Jun 2012)
ISSN: 1769-6690 [Electronic] France |
PMID | 22542764
(Publication Type: Journal Article, Review)
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Copyright | Copyright © 2012. Published by Elsevier SAS. |
Chemical References |
- Anti-Bacterial Agents
- Cloxacillin
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Topics |
- Anti-Bacterial Agents
(administration & dosage, pharmacology)
- Cloxacillin
(administration & dosage, pharmacology)
- Humans
- Injections, Intravenous
- Inpatients
- Microbial Sensitivity Tests
- Staphylococcal Infections
(drug therapy)
- Staphylococcus aureus
(drug effects)
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