Abstract | OBJECTIVE:
Tinnitus is defined as an intrinsic sound sensation that cannot be attributed to an external sound source. Currently there are no standardized drug therapies for the treatment of tinnitus. Based on the analogy between pain and tinnitus it is suggested that among all antidepressant families that have been used for tinnitus, particular interest should be paid to the tricyclic group of drugs as they have an analgesic effect. The aim of the present study was to investigate the effect of a tricyclic pharmacological agent, namely cyclobenzaprine for the relief of tinnitus complaints. SUBJECTS AND METHODS: 65 patients, who received the drug treatment, were compared to 30 patients on a waiting list, who received no treatment. RESULTS: CONCLUSION: Our results indicate that cyclobenzaprine is a promising drug to treat tinnitus particularly in certain subgroups. As there is a good risk-benefit ratio and there are currently no well-established, specific treatments for tinnitus, cyclobenzaprine might be worthwhile to further investigate.
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Authors | Sven Vanneste, Ricardo Figueiredo, Dirk De Ridder |
Journal | International journal of clinical pharmacology and therapeutics
(Int J Clin Pharmacol Ther)
Vol. 50
Issue 5
Pg. 338-44
(May 2012)
ISSN: 0946-1965 [Print] Germany |
PMID | 22541838
(Publication Type: Journal Article)
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Chemical References |
- Antidepressive Agents, Tricyclic
- Muscle Relaxants, Central
- Amitriptyline
- cyclobenzaprine
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Topics |
- Adult
- Aged
- Amitriptyline
(analogs & derivatives, pharmacology, therapeutic use)
- Antidepressive Agents, Tricyclic
(therapeutic use)
- Female
- Humans
- Male
- Middle Aged
- Muscle Relaxants, Central
(therapeutic use)
- Tinnitus
(drug therapy)
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