Abstract | PURPOSE: To assess associations between visual acuity (VA) and the status of the photoreceptor inner segment-outer segment (IS-OS) junction in a subset of patients in the Standard Care vs COrticosteroid for REtinal Vein Occlusion (SCORE) Study. METHODOLOGY: High-resolution time domain optical coherence tomography (OCT) scans of study eyes from a single site participating in the SCORE Study were evaluated. Integrity of the IS-OS junction in the central subfield was evaluated using a three-step scale: absent, abnormal or normal. Associations of the IS-OS status with ETDRS VA letter score and center point thickness ( CPT) were investigated. RESULTS: Baseline OCTs of 42 eyes were evaluated. The IS-OS junction was absent in 30 (71%) and abnormal in 12 (29%). At month 12, the IS-OS junction was absent in 18 (43%), abnormal in 12 (28%), and normal in 12 (28%) eyes. At baseline, IS-OS status was significantly associated with CPT, but not with VA. At month 12, IS-OS status was significantly associated with CPT and VA, that is, absent or abnormal IS-OS was associated with increased CPT and worse VA. Change in IS-OS status was not associated with change in CPT (P=0.8). Worsening of IS-OS status was associated with loss of VA and improvement in IS-OS status to normal was associated with gain in VA (P=0.03). CONCLUSION: In this data set with long-term follow-up of OCTs as part of the SCORE Study, there is a correlation between change in IS-OS status and VA. This supports further evaluation of outer retinal morphology in larger data sets.
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Authors | A Domalpally, Q Peng, R Danis, B Blodi, I U Scott, M Ip, SCORE Study Research Group |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 26
Issue 7
Pg. 919-24
(Jul 2012)
ISSN: 1476-5454 [Electronic] England |
PMID | 22538214
(Publication Type: Journal Article)
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Topics |
- Cohort Studies
- Humans
- Retinal Photoreceptor Cell Inner Segment
(pathology, physiology)
- Retinal Photoreceptor Cell Outer Segment
(pathology, physiology)
- Retinal Vein Occlusion
(physiopathology)
- Tomography, Optical Coherence
(methods)
- Visual Acuity
(physiology)
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