Regenerative wound healing in acute degree III mandibular defects in dogs.

Abstract

OBJECTIVE:

To evaluate the healing events in degree III furcation defects in dogs following the application of the combination of an enamel matrix derivative with a biphasic calcium phosphate (Emdogain Plus).

METHOD AND MATERIALS:

Seventeen degree III furcation defects, 5 mm high and 4 mm wide, were created in 9 dogs. In both groups, the defects were conditioned with EDTA. One defect was treated with Emdogain Plus (n = 9), while the contralateral defect serving as control remained empty (n = 8). The defects in both groups were fully covered by coronally repositioned flaps. After 5 months of healing, histologic and histometric analysis was preformed.

RESULTS:

A significant amount of new attachment and bone formation was observed in both control and test specimens. However, in a number of control specimens, ankylosis was also observed. In the control and test groups, respectively, the mean new cementum length was 10.8 ± 2.1 mm and 8.6 ± 3.2 mm; the mean periodontal ligament length was 7.6 ± 3.8 mm and 8.1 ± 4.0 mm. The mean new bone height was 4.4 ± 1.3 mm and 4.3 ± 1.6 mm in the control and test groups, respectively. No statistical differences were found between the two groups in terms of amount of cementum, periodontal ligament, and alveolar bone regeneration.

CONCLUSION:

The present study failed to show higher amounts of newly formed cementum and bone following treatment of acute degree III mandibular furcation defects following use of Emdogain Plus compared with a coronally advanced flap. Emdogain Plus seems to have a protective role against ankylosis in this type of defect.

• Authors: Nikos Mardas, Michael Kraehenmann, Michel Dard
• Journal: Quintessence international (Berlin, Germany : 1985) (Quintessence Int) Vol. 43 Issue 5 Pg. e48-59 (May 2012) ISSN: 1936-7163 [Electronic] Germany
• PMID: 22536596 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Bone Substitutes
• Chelating Agents
• Dental Enamel Proteins
• Hydroxyapatites
• enamel matrix proteins
• hydroxyapatite-beta tricalcium phosphate
• Collagen
• Edetic Acid

Topics

• Alveolar Process (pathology)
• Animals
• Bicuspid (drug effects, pathology)
• Bone Regeneration (physiology)
• Bone Substitutes (therapeutic use)
• Chelating Agents (therapeutic use)
• Collagen
• Dental Cementum (pathology)
• Dental Enamel Proteins (therapeutic use)
• Dogs
• Edetic Acid (therapeutic use)
• Female
• Furcation Defects (classification, surgery)
• Gingiva (pathology)
• Guided Tissue Regeneration, Periodontal (methods)
• Hydroxyapatites (therapeutic use)
• Mandibular Diseases (classification, surgery)
• Osteogenesis (physiology)
• Periodontal Ligament (pathology)
• Postoperative Complications
• Random Allocation
• Surgical Flaps
• Time Factors
• Tooth Ankylosis (etiology, pathology)
• Tooth Root (drug effects)
• Wound Healing (physiology)