Antidepressants and menstruation disorders in women: a cross-sectional study in three centers.

Abstract

OBJECTIVE:

The relationship between menstruation disorders and antidepressant drugs usage in women remains unclear. In this study, we aimed to investigate the incidence rate of antidepressant-related menstruation disorders and to examine whether or not antidepressant use is associated with menstrual disorders in women.

METHODS:

The study sample was gathered from three centers and four hospitals. A total of 1432 women who met the criteria of inclusion were included in the study. The sample was divided into two groups: the antidepressant group (n=793) and the control group (n=639). The menstruation disorders were established with reports from the study participants on the basis of related gynecological descriptions.

RESULTS:

The prevalence of menstrual disorders was significantly higher in the antidepressant group (24.6%) than the control group (12.2%). The incidence of antidepressant-induced menstruation disorder was 14.5%. The antidepressants most associated with menstrual disorders were paroxetine, venlafaxine, sertraline and their combination with mirtazapine. Overall, the incidence rate was similar in women receiving selective serotonin reuptake inhibitors and serotonin noradrenaline reuptake inhibitors.

CONCLUSIONS:

The results of the present study suggest that menstruation disorders are frequently observed in women taking antidepressants and that it appears to be associated with antidepressant use at least in some women.

• Authors: Faruk Uguz, Mine Sahingoz, Seyit Ali Kose, Ozgur Ozbebit, Cem Sengul, Yavuz Selvi, Ceyhan Balci Sengul, Medine Gıynas Ayhan, Adnan Dagistanli, Rustem Askin
• Journal: General hospital psychiatry (Gen Hosp Psychiatry) 2012 Sep-Oct Vol. 34 Issue 5 Pg. 529-33 ISSN: 1873-7714 [Electronic] United States
• PMID: 22534402 (Publication Type: Comparative Study, Journal Article, Multicenter Study)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Antidepressive Agents
• Cyclohexanols
• Mianserin
• Paroxetine
• Venlafaxine Hydrochloride
• Mirtazapine
• Sertraline

Topics

• Adolescent
• Adult
• Ambulatory Care
• Antidepressive Agents (adverse effects)
• Cross-Sectional Studies
• Cyclohexanols (adverse effects)
• Female
• Humans
• Menstruation Disturbances (chemically induced, epidemiology)
• Mianserin (adverse effects, analogs & derivatives)
• Mirtazapine
• Paroxetine (adverse effects)
• Qualitative Research
• Sertraline (adverse effects)
• Turkey (epidemiology)
• Venlafaxine Hydrochloride
• Young Adult