Abstract |
There is limited evidence for the management of sexual dysfunction and/or hyperprolactinemia resulting from use of antipsychotics in patients with schizophrenia and spectrum. The aim of this study was to review and describe the strategies for the treatment of antipsychotic-induced sexual dysfunctions and/or hyperprolactinemia. The research was carried out through Medline/PubMed, Cochrane, Lilacs, Embase, and PsycINFO, and it included open labels or randomized clinical trials. The authors found 31 studies: 25 open-label noncontrolled studies and 6 randomized controlled clinical trials. The randomized, double-blind controlled studies that were conducted with adjunctive treatment that showed improvement of sexual dysfunction and/or decrease of prolactin levels were sildenafil and aripiprazole. The medication selegiline and cyproheptadine did not improve sexual function. The switch to quetiapine was demonstrated in 2 randomized controlled studies: 1 showed improvement in the primary outcome and the other did not. This reviewed data have suggested that further well-designed randomized controlled trials are needed to provide evidence for the effects of different strategies to manage sexual dysfunction and/or hyperprolactinaemia resulting from antipsychotics. These trials are necessary in order to have a better compliance and reduce the distress among patients with schizophrenia.
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Authors | Luciana Vargas Alves Nunes, Hugo Cogo Moreira, Denise Razzouk, Sandra Odebrecht Vargas Nunes, Jair De Jesus Mari |
Journal | Journal of sex & marital therapy
(J Sex Marital Ther)
Vol. 38
Issue 3
Pg. 281-301
( 2012)
ISSN: 1521-0715 [Electronic] England |
PMID | 22533871
(Publication Type: Journal Article, Review)
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Chemical References |
- Antipsychotic Agents
- Piperazines
- Purines
- Quinolones
- Sulfones
- Vasodilator Agents
- Aripiprazole
- Sildenafil Citrate
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Topics |
- Adult
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Aripiprazole
- Drug Substitution
- Drug Therapy, Combination
- Erectile Dysfunction
(chemically induced, drug therapy, prevention & control)
- Female
- Humans
- Hyperprolactinemia
(chemically induced, prevention & control)
- Male
- Piperazines
(administration & dosage, therapeutic use)
- Psychotic Disorders
(drug therapy, psychology)
- Purines
(administration & dosage)
- Quinolones
(therapeutic use)
- Schizophrenia
(drug therapy)
- Schizophrenic Psychology
- Sexual Dysfunction, Physiological
(chemically induced, drug therapy, prevention & control)
- Sildenafil Citrate
- Sulfones
(administration & dosage)
- Vasodilator Agents
(administration & dosage)
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