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Genetic characterization of astroviruses detected in guinea fowl (Numida meleagris) reveals a distinct genotype and suggests cross-species transmission between turkey and guinea fowl.

Abstract
Astroviruses can infect mammalian and avian species and are often responsible for gastroenteric disease symptoms. In this study, the complete open reading frame (ORF) 2, the 3' end of ORF1b and the corresponding intergenic region of astroviruses identified in farmed guinea fowl (Numida meleagris) were sequenced and genetically analysed. Overall, the genetic sequence of guinea fowl astroviruses was related to turkey astrovirus type 2 (TastV2), although a marked genetic distance was revealed based on ORF2, which might indicate the circulation of a distinct virus genotype and serotype in guinea fowl. Furthermore, the genetic data presented herein suggest that either recombination between different astroviruses infecting distinct hosts or adaptation of a given astrovirus to a new host had occurred. In either case, direct or indirect interspecies transmission of astroviruses is likely to have occurred between turkey and guinea fowl, indicating the ability of viruses belonging to the family Astroviridae to cross species barriers.
AuthorsCristian De Battisti, Annalisa Salviato, Christine Monceyron Jonassen, Anna Toffan, Ilaria Capua, Giovanni Cattoli
JournalArchives of virology (Arch Virol) Vol. 157 Issue 7 Pg. 1329-37 (Jul 2012) ISSN: 1432-8798 [Electronic] Austria
PMID22527867 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Viral Proteins
Topics
  • Amino Acid Sequence
  • Animals
  • Astroviridae Infections (transmission, veterinary, virology)
  • Avastrovirus (classification, genetics)
  • Base Sequence
  • Galliformes
  • Gene Expression Regulation, Viral (physiology)
  • Genotype
  • Open Reading Frames (genetics)
  • Phylogeny
  • Poultry Diseases (transmission, virology)
  • Reverse Transcriptase Polymerase Chain Reaction (veterinary)
  • Sequence Alignment (veterinary)
  • Species Specificity
  • Turkeys
  • Viral Proteins (genetics, metabolism)

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