Abstract | BACKGROUND: Since 1996, transcatheter renal artery embolization (renal TAE) has been performed to reduce the volume of the kidneys in patients with autosomal dominant polycystic kidney disease ( ADPKD) and complications of nephromegaly at our hospital. Respiratory dysfunction is often a serious problem in these patients before TAE. PATIENTS AND METHODS: Between January 2006 and October 2008, renal TAE was performed and lung function testing [percent vital capacity (%VC) and percent forced expiratory volume in 1 s (%FEV(1.0))] was done by spirometry in 28 patients on maintenance hemodialysis who had respiratory symptoms. RESULTS: Renal volume was 6,330.5 ± 3,126.5 cm(3) (range 1,771-12,761 cm(3)) before TAE, and decreased significantly to 2,892.2 ± 1,841.7 cm(3) (range 622-6,961 cm(3)) by 12 months after TAE (p = 0.0001). The percent decrease of renal volume at 12 months after TAE versus baseline was 45.6 ± 14.6% (range 6.6-67.3%). %VC showed a significant increase from 95.9 ± 14.8% (range 63-127%) before renal TAE to 100.1 ± 11.7% (range 78-120%) at 12 months after TAE (p < 0.01). %FEV(1.0) was also significantly increased from 87.9 ± 15.0% (range 55-110%) before renal TAE to 92.5 ± 14.4% (range 58.0-115.0%) at 12 months after TAE (p < 0.01). The changes of VC (ΔVC%) and FEV(1.0) (ΔFEV(1.0)%) both showed a significant positive correlation with the reduction of renal volume (Δ renal volume) (p = 0.001 and p = 0.004, respectively). CONCLUSION: Since TAE not only led to a significant decrease of renal volume in ADPKD patients with nephromegaly, but also improved lung function (both %VC and %FEV(1.0)), pulmonary dysfunction should be recognized as one of the extrarenal complications of ADPKD.
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Authors | Shiho Yamakoshi, Yoshifumi Ubara, Tatsuya Suwabe, Rikako Hiramatsu, Masayuki Yamanouchi, Noriko Hayami, Keiichi Sumida, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Kennmei Takaichi, Masateru Kawabata |
Journal | Clinical and experimental nephrology
(Clin Exp Nephrol)
Vol. 16
Issue 5
Pg. 773-8
(Oct 2012)
ISSN: 1437-7799 [Electronic] Japan |
PMID | 22526485
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Catheterization
- Embolization, Therapeutic
- Female
- Humans
- Kidney
(pathology)
- Lung Diseases
(etiology, therapy)
- Male
- Middle Aged
- Organ Size
- Polycystic Kidney, Autosomal Dominant
(complications, therapy)
- Renal Artery
- Renal Dialysis
- Respiratory Function Tests
- Treatment Outcome
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