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The antioxidant properties of high-density lipoproteins in atherosclerosis.

Abstract
High-density lipoprotein (HDL) is protective against atherosclerosis development. Other than its central role in reverse cholesterol transport, HDL exhibits several other mechanisms by which it is protective. These include antioxidative, anti-inflammatory and antiapoptopic activities and the normalisation of vascular function. In light of the current view that oxidative modification of low-density lipoprotein (LDL) is essential for the initiation and progression of atherosclerosis, the antioxidative properties of HDL may be an important protective mechanism. HDL can retard the oxidation of LDL and limit its atherogenicity. Several proteins are present on HDL and the evidence that some of them metabolise lipid peroxidation products of phospholipids, cholesteryl esters and triglycerides associated with LDL and vascular cell membranes are discussed in this review.
AuthorsB Mackness, M Mackness
JournalPanminerva medica (Panminerva Med) Vol. 54 Issue 2 Pg. 83-90 (Jun 2012) ISSN: 1827-1898 [Electronic] Italy
PMID22525563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Antioxidants
  • Apolipoprotein A-I
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Phosphatidylcholine-Sterol O-Acyltransferase
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • Aryldialkylphosphatase
Topics
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase (physiology)
  • Animals
  • Antioxidants (pharmacology)
  • Apolipoprotein A-I (physiology)
  • Aryldialkylphosphatase (physiology)
  • Atherosclerosis (metabolism)
  • Humans
  • Lipoproteins, HDL (pharmacology)
  • Lipoproteins, LDL (metabolism)
  • Oxidation-Reduction
  • Phosphatidylcholine-Sterol O-Acyltransferase (physiology)

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