Abstract | PURPOSE: METHODS: We retrospectively reviewed the records of consecutive patients referred to Vanderbilt Children's Hospital for the treatment of periorbital infections to identify cases associated with the use of Dermabond. The clinical features and outcomes of each case were reviewed. We performed a meta-analysis of published cases to identify any association of tissue adhesive with wound infection rate. RESULTS: The review identified 3 patients, all of whom were younger than 3 years of age and developed cellulitis within 24 hours of wound closure. Broad-spectrum intravenous antibiotic therapy was started in less than 3 hours in all cases. Cultures were obtained in 2 of the 3 cases; both grew Streptococcus pyogenes. Two cases required surgical intervention, including one with necrotizing fasciitis. In the meta-analysis, the wound infection rate was 1.8% in tissue adhesive closure and 0.3% in standard wound closure (odds ratio 6.0; 95% confidence interval 0.7-50.3, P = 0.06). CONCLUSIONS:
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Authors | Ruth H Yeilding, Denis M O'Day, Chun Li, Pauline T Alexander, Louise A Mawn |
Journal | Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus
(J AAPOS)
Vol. 16
Issue 2
Pg. 168-72
(Apr 2012)
ISSN: 1528-3933 [Electronic] United States |
PMID | 22525174
(Publication Type: Case Reports, Journal Article, Meta-Analysis, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 American Association for Pediatric Ophthalmology and Strabismus. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Anti-Bacterial Agents
- Cyanoacrylates
- Tissue Adhesives
- octyl 2-cyanoacrylate
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Topics |
- Anti-Bacterial Agents
(administration & dosage)
- Child, Preschool
- Combined Modality Therapy
- Cyanoacrylates
(therapeutic use)
- Eye Infections, Bacterial
(diagnosis, microbiology, therapy)
- Eye Injuries, Penetrating
(drug therapy, microbiology)
- Eyebrows
- Fasciitis, Necrotizing
(diagnosis, microbiology, therapy)
- Female
- Humans
- Infant
- Infusions, Intravenous
- Lacerations
(drug therapy)
- Male
- Ophthalmologic Surgical Procedures
- Orbital Cellulitis
(diagnosis, microbiology, therapy)
- Retrospective Studies
- Streptococcal Infections
(diagnosis, microbiology, therapy)
- Streptococcus pyogenes
(isolation & purification)
- Tissue Adhesives
(therapeutic use)
- Wound Infection
(diagnosis, microbiology, therapy)
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