Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.

Abstract

We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomography. He was treated with 5-fluorouracil, leucovorin and oxaliplatin (100 mg/m(2)). After eight cycles of treatment and a cumulative oxaliplatin dose of 780 mg/m(2), he developed an unsteady gait, dysphagia, weakness of both the upper and lower limbs and impairment of all sensory modalities. Nerve conduction studies confirmed the diagnosis of AIDP. Immunoglobulin G i.v. was administered for 5 days but the neurological deficits of both his upper and lower limbs did not improve. This case highlights unusual peripheral nervous system manifestations in a patient who received chemotherapy with oxaliplatin.

• Authors: Ju Young Yoon, Tai Seung Nam, Myeong Kyu Kim, Jun Eul Hwang, Hyun-Jeong Shim, Sang Hee Cho, Ik Joo Chung, Woo Kyun Bae
• Journal: Asia-Pacific journal of clinical oncology (Asia Pac J Clin Oncol) Vol. 8 Issue 2 Pg. 201-4 (Jun 2012) ISSN: 1743-7563 [Electronic] Australia
• PMID: 22524580 (Publication Type: Case Reports, Journal Article)
• Copyright: © 2012 Blackwell Publishing Asia Pty Ltd.

Chemical References

• Organoplatinum Compounds
• Oxaliplatin
• Leucovorin
• Fluorouracil

Topics

• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, adverse effects)
• Bile Duct Neoplasms (drug therapy)
• Cholangiocarcinoma (drug therapy)
• Fluorouracil (administration & dosage, adverse effects)
• Guillain-Barre Syndrome (chemically induced, diagnosis)
• Humans
• Leucovorin (administration & dosage, adverse effects)
• Liver Neoplasms (drug therapy)
• Male
• Middle Aged
• Organoplatinum Compounds (administration & dosage, adverse effects)
• Oxaliplatin