Pulmonary capillaritis and glomerulonephritis in an antineutrophil cytoplasmic antibody-positive patient with prior granulomatous aortitis.

Abstract

A 59-year-old man showed asynchronous development of noninfectious granulomatous aortitis with aneurysm, followed 9 months later by pulmonary capillaritis and glomerulonephritis in association with elevated serum antineutrophil cytoplasmic antibody levels. To our knowledge, the combination of large artery vasculitis and small vessel systemic vasculitis (capillaritis) has not been previously reported. This case may represent a hybrid type of systemic vasculitis combining features of giant cell arteritis and Wegener's granulomatosis.

• Authors: S C Sieber, B Cuello, N A Gelfman, H B Garfinkel
• Journal: Archives of pathology & laboratory medicine (Arch Pathol Lab Med) Vol. 114 Issue 12 Pg. 1223-6 (Dec 1990) ISSN: 0003-9985 [Print] United States
• PMID: 2252417 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies

Topics

• Antibodies (immunology)
• Capillaries (pathology)
• Cytoplasm (immunology)
• Giant Cell Arteritis (complications, pathology)
• Glomerulonephritis (etiology, pathology)
• Granulomatosis with Polyangiitis (complications, pathology)
• Humans
• Lung (blood supply)
• Male
• Middle Aged
• Neutrophils (immunology)
• Vasculitis (etiology, pathology)