Abstract | INTRODUCTION: Involution of terminal duct lobular units (TDLUs), the structures that give rise to most breast cancers, has been associated with reduced breast cancer risk. Data suggest that the etiology and pathogenesis of luminal A and core basal phenotype (CBP) breast cancers differ, but associations with TDLU involution are unknown. Accordingly, we performed a masked microscopic assessment of TDLU involution in benign tissues associated with luminal A and CBP breast cancers diagnosed among women less than age 55 years. METHODS: RESULTS: Among 232 luminal A and 49 CBP cancers associated with evaluable TDLUs, CBP tumors were associated with significantly greater average number of acini per TDLU (odds ratio (OR) = 3.36, 95% confidence interval (CI) = 1.36 to 8.32, P = 0.009) and larger average TDLU diameter (OR = 2.49, 95% CI = 1.08 to 5.74, P = 0.03; comparing highest to lowest group, adjusted for age and study site). CONCLUSIONS: We suggest that TDLU involution is less marked in benign tissues surrounding CBP as compared to luminal A cancers, which may reflect differences in the etiology and pathogenesis of these tumor subtypes.
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Authors | Xiaohong R Yang, Jonine D Figueroa, Roni T Falk, Hong Zhang, Ruth M Pfeiffer, Stephen M Hewitt, Jolanta Lissowska, Beata Peplonska, Louise Brinton, Montserrat Garcia-Closas, Mark E Sherman |
Journal | Breast cancer research : BCR
(Breast Cancer Res)
Vol. 14
Issue 2
Pg. R64
(Apr 18 2012)
ISSN: 1465-542X [Electronic] England |
PMID | 22513288
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Intramural)
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Chemical References |
- Biomarkers, Tumor
- Receptors, Estrogen
- Receptors, Progesterone
- EGFR protein, human
- ERBB2 protein, human
- ErbB Receptors
- Receptor, ErbB-2
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(metabolism, pathology)
- Case-Control Studies
- ErbB Receptors
(metabolism)
- Female
- Humans
- Logistic Models
- Middle Aged
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
- Receptors, Progesterone
(metabolism)
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