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Spontaneous splenic rupture in dengue fever with non-fatal outcome in an adult.

Abstract
A 26-year-old male presented with fever for five days and abdominal pain for 24 hours. System examination identified a soft abdomen with diffuse tenderness. CT-abdomen findings were consistent with splenic rupture with intra and peri-splenic hematoma. Laboratory investigations showed a platelet count of 40,000 per mm(3). In due course he developed hypotension and underwent splenectomy. Non-structural protein 1 (NS1) dengue antigen was positive in the admission sample and IgM dengue antibodies were detected in the follow-up sample. Histopathology of the spleen showed normal architecture with no evidence of hyperplasia, cellular infiltrates or haematological malignancy. Splenic rupture is a rare, but potentially fatal complication of dengue fever and severe dengue which should be suspected when a patient presents with abdominal pain and hypotension. Our case highlights the occurrence of splenic rupture in the viremic phase of dengue illness before the development of IgM antibodies
AuthorsEmmanuel Bhaskar, Swathy Moorthy
JournalJournal of infection in developing countries (J Infect Dev Ctries) Vol. 6 Issue 4 Pg. 369-72 (Apr 13 2012) ISSN: 1972-2680 [Electronic] Italy
PMID22505449 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antibodies, Viral
  • Antigens, Viral
  • Immunoglobulin M
Topics
  • Abdominal Pain (diagnosis, etiology)
  • Adult
  • Antibodies, Viral (blood)
  • Antigens, Viral (blood)
  • Dengue (complications)
  • Hematoma (diagnosis, pathology)
  • Humans
  • Hypotension (diagnosis, etiology)
  • Immunoglobulin M (blood)
  • Male
  • Radiography, Abdominal
  • Splenectomy
  • Splenic Rupture (complications, diagnosis, pathology, surgery)
  • Tomography, X-Ray Computed

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