Abstract |
The aim of the study was to assess lung function longitudinally after neonatal extracorporeal membrane oxygenation (ECMO), and to identify any effects of diagnosis and perinatal characteristics. 121 neonatal ECMO-treated children (70 with meconium aspiration syndrome, 20 congenital diaphragmatic hernia and 31 with other diagnoses) performed a total of 191 lung function measurements at 5, 8 and/or 12 yrs. We assessed dynamic and static lung volumes, reversibility of airway obstruction and diffusion capacity. Mean SDS forced expiratory volume in 1 s (FEV(1)) at 5 yrs before and after bronchodilation (-0.51 and 0.07) was significantly higher than at 8 (-0.79 and -0.4; p<0.04) and 12 yrs (-1.10 and -0.52; p<0.003). Mean SDS for all spirometric parameters before and after bronchodilation were significantly lower in the congenital diaphragmatic hernia group compared with the other diagnostic groups (all p ≤ 0.025). A significant volume of trapped air was observed in 86% patients with congenital diaphragmatic hernia, 50% with meconium aspiration syndrome and 58% with other diagnoses. After bronchodilation, mean SDS FEV(1) and forced vital capacity were negatively influenced by duration of ventilation (both p<0.001) and duration of ECMO (p=0.003 and p=0.02, respectively). Long-term pulmonary sequelae after neonatal ECMO-treatment mainly occur in congenital diaphragmatic hernia patients and tend to deteriorate over time.
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Authors | Marjolein Spoel, Roxanne Laas, Saskia J Gischler, Wim J C Hop, Dick Tibboel, Johan C de Jongste, Hanneke Ijsselstijn |
Journal | The European respiratory journal
(Eur Respir J)
Vol. 40
Issue 6
Pg. 1531-7
(Dec 2012)
ISSN: 1399-3003 [Electronic] England |
PMID | 22496333
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Child
- Child, Preschool
- Cohort Studies
- Extracorporeal Membrane Oxygenation
(adverse effects)
- Female
- Follow-Up Studies
- Forced Expiratory Volume
- Hernia, Diaphragmatic
(pathology, therapy)
- Hernias, Diaphragmatic, Congenital
- Humans
- Infant, Newborn
- Lung
(pathology)
- Lung Diseases
(etiology)
- Male
- Meconium Aspiration Syndrome
(pathology, therapy)
- Prospective Studies
- Spirometry
(methods)
- Treatment Outcome
- Vital Capacity
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