Early administration of low-dose aspirin for the prevention of severe and mild preeclampsia: a systematic review and meta-analysis.

Abstract

OBJECTIVE:

To determine whether early administration of aspirin prevents severe and mild preeclampsia.

STUDY DESIGN:

A systematic review and meta-analysis of randomized controlled trials were performed. Studies in which women were randomized at or before 16 weeks' gestation to low-dose aspirin versus placebo or no treatment were included. The outcomes of interest were severe preeclampsia and mild preeclampsia. Pooled relative risks with their 95% confidence intervals (CIs) were calculated.

RESULTS:

Among 7941 citations retrieved, 352 were completely reviewed and four studies (392 women) fulfilled the inclusion criteria and were analyzed. When compared with controls, aspirin started at ≤16 weeks was associated with a significant reduction in severe (relative risk: 0.22, 95% CI: 0.08 to 0.57) but not mild (relative risk: 0.81, 95% CI: 0.33 to 1.96) preeclampsia.

CONCLUSION:

Low-dose aspirin initiated at or before 16 weeks reduces the risk of severe preeclampsia, but not mild preeclampsia.

• Authors: Stéphanie Roberge, Yves Giguère, Pia Villa, Kypros Nicolaides, Merja Vainio, Jean-Claude Forest, Peter von Dadelszen, Peter von Dadelzen, Daniel Vaiman, Sylvie Tapp, Emmanuel Bujold
• Journal: American journal of perinatology (Am J Perinatol) Vol. 29 Issue 7 Pg. 551-6 (Aug 2012) ISSN: 1098-8785 [Electronic] United States
• PMID: 22495898 (Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
• Copyright: Copyright © 2012 by Thieme Medical Publishers

Chemical References

• Platelet Aggregation Inhibitors
• Aspirin

Topics

• Aspirin (therapeutic use)
• Female
• Humans
• Platelet Aggregation Inhibitors (therapeutic use)
• Pre-Eclampsia (prevention & control)
• Pregnancy
• Severity of Illness Index