Abstract | OBJECTIVE: METHODS: RESULTS: Inflammatory agents including TNF-alpha, sP- selectin and sICAM-1 increased in diabetic rats to compare with control group. Treatment with ALA significantly decreased TNF-alpha, sP- selectin and slCAM-1 to compare with diabetic group. Furthermore, compared with control group, serum MDA production increased whereas NO production, SOD and CAT activities decreased in diabetic rats. Treatment with ALA reduced MDA production, increased NO production, promoted SOD and CAT activities compared with diabetic group. CONCLUSION: These results indicate that diet rich in ALA exerted the anti-inflammatory and anti-oxidative effects in diabetic rats, which may be beneficial to the prevention and treatment of diabetes.
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Authors | Li-Hua Zhang, Wei Zhang, Guang-Hong Wei, Pei Yang, Jun Liu, Xiao-Lin Niu |
Journal | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology
(Zhongguo Ying Yong Sheng Li Xue Za Zhi)
Vol. 28
Issue 1
Pg. 64-7
(Jan 2012)
ISSN: 1000-6834 [Print] China |
PMID | 22493899
(Publication Type: English Abstract, Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
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Chemical References |
- Tumor Necrosis Factor-alpha
- alpha-Linolenic Acid
- Malondialdehyde
- Superoxide Dismutase
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Topics |
- Animals
- Diabetes Mellitus, Experimental
(drug therapy, metabolism)
- Diabetes Mellitus, Type 2
(drug therapy, metabolism)
- Inflammation
- Male
- Malondialdehyde
(blood)
- Oxidative Stress
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Superoxide Dismutase
(blood)
- Tumor Necrosis Factor-alpha
(blood)
- alpha-Linolenic Acid
(pharmacology, therapeutic use)
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