Adrenocortical function in the postoperative pediatric cardiac surgical patient.

Abstract

PURPOSE OF REVIEW:

Corticosteroids are frequently used in the postoperative care of children with congenital heart disease. This review describes the function of the adrenocortical axis in this population and the effects of corticosteroids on cardiovascular function. In addition, it examines the diagnosis of adrenal insufficiency in this population and provides an overview of recent studies on the use of steroids in treating hemodynamic instability in these children.

RECENT FINDINGS:

Corticosteroids improve hemodynamic parameters in children with shock following congenital heart surgery. This improvement may be due to treatment of adrenal insufficiency or from direct cardiovascular effects of corticosteroids. The diagnosis of adrenal insufficiency in this population is challenging as low cortisol levels do not consistently correlate with adverse outcomes.

SUMMARY:

Because of the lack of evidence delineating what the normal adrenocortical function is in this population, cortisol levels alone are not sufficient to justify treating with steroids in this population. Corticosteroids are beneficial in improving hemodynamics in children with shock after congenital heart surgery, but the adverse effects of the therapy in this context are not fully known. Prospective trials are necessary to clarify which patients may benefit from steroid therapy and to examine long-term effects of steroids.

• Authors: Michael L Green, Josh Koch
• Journal: Current opinion in pediatrics (Curr Opin Pediatr) Vol. 24 Issue 3 Pg. 285-90 (Jun 2012) ISSN: 1531-698X [Electronic] United States
• PMID: 22491492 (Publication Type: Journal Article, Review)

Chemical References

• Glucocorticoids

Topics

• Adrenal Insufficiency (diagnosis, drug therapy, etiology)
• Child
• Glucocorticoids (therapeutic use)
• Heart Defects, Congenital (surgery)
• Humans
• Postoperative Care (methods)
• Postoperative Complications (diagnosis, drug therapy)
• Risk Factors