Thymoma and solid-organ transplantation.

Abstract

Solid-organ-transplant recipients are at high risk of developing cancer, including thoracic malignancies. Herein, we report on two cases of thymoma in solid-organ recipients. One case was a female kidney-transplant recipient who had a type B2, Masaoka stage IVA thymoma that was treated by extended surgical resection followed by postoperative radiation therapy. The second case was type A Masaoka II thymoma that occurred after a liver transplant. The role of EBV in the oncogenesis of thymoma is controversial. We suggest that viruses may induce neoplasms in this specific population, as observed in post-transplant lymphoproliferative disorders. However, Epstein-Barr-encoded RNA (EBER) was negative in both patients.

• Authors: Nicolas Guibert, Laurent Brouchet, Isabelle Rouquette, Alain Didier, Lionel Rostaing, Nassim Kamar, Julien Mazieres
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 77 Issue 1 Pg. 232-4 (Jul 2012) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 22487431 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

Topics

• Aged
• Epstein-Barr Virus Infections (diagnosis, etiology)
• Female
• Humans
• Kidney (virology)
• Kidney Transplantation (adverse effects)
• Liver (virology)
• Liver Transplantation (adverse effects)
• Male
• Middle Aged
• Radionuclide Imaging
• Thymoma (diagnostic imaging, etiology, therapy)
• Thymus Neoplasms (diagnostic imaging, etiology, therapy)