Abstract | BACKGROUND: METHODS: A double-blind prospective randomized clinical trial was performed on 45 patients candidate for fusion of lumbar spondylolisthesis. Patients were divided into two groups of A (treatment) and B (control). In group A, pain was controlled by intravenous infusion of ketamine. Morphine was also administrated when the patients scored their pain above 4 on a visual analogue scale (VAS). In group B, intravenous infusions of morphine were performed every 6 hours. VAS and whole dosage of morphine were compared between two groups every 6 hours. RESULTS:
Morphine and ketamine were both effective on pain control. Mean values of pain intensity at the first to fourth time points were 2.1, 1.8, 1.6, and 1.7 in group A and 3.9, 3.4, 3.5, and 3.5 in group B, respectively (p < 0.01 for all periods). However, ketamine was more efficient in pain reduction during the first 24 hours (p < 0.001). CONCLUSION:
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Authors | Saeed Abrishamkar, Nourallah Eshraghi, Awat Feizi, Reihanak Talakoub, Ahmadreza Rafiei, Payman Rahmani |
Journal | Medicinski arhiv
(Med Arh)
Vol. 66
Issue 2
Pg. 107-10
( 2012)
Bosnia and Herzegovina |
PMID | 22486142
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Analgesics
- Analgesics, Opioid
- Ketamine
- Morphine
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Topics |
- Adult
- Aged
- Analgesics
(administration & dosage)
- Analgesics, Opioid
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Infusions, Intravenous
- Internal Fixators
- Ketamine
(administration & dosage)
- Lumbar Vertebrae
(surgery)
- Male
- Middle Aged
- Morphine
(administration & dosage)
- Pain Measurement
- Pain, Postoperative
(prevention & control)
- Spinal Fusion
(instrumentation)
- Spondylolisthesis
(surgery)
- Young Adult
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