Abstract | BACKGROUND: METHODS: We measured FGF-23 levels before and at 1, 2, 4, and 12 weeks after transplantation in 20 renal transplant recipients. Serum creatinine, calcium (Ca), phosphate (Pi), intact PTH (PTH), and 1,25-dihydroxy vitamin D (1,25( OH)(2)VitD) were measured at the same time. RESULTS: FGF-23 levels decreased by 97% at 4 weeks after renal transplantation (PRT) (7,471 ± 11,746 vs 225 ± 295 pg/mL; P < .05) but were still above normal. PTH and Pi levels also decreased significantly after renal transplantation, and Ca and 1,25( OH)(2)VitD slightly increased. PRT hypophosphatemia of <2.5 mg/dL developed in 15 (75%) and 12 (60%) patients at 4 weeks and 12 weeks respectively. Compared with nonhypophosphatemic patients, the levels of FGF-23 of hypophosphatemic patients were higher (303 ± 311 vs 10 ± 6.9 pg/mL; P = .02) at 4 weeks PRT. FGF-23 levels were inversely correlated with Pi (r(2) = 0.406; P = .011); PTH was not independently associated with Pi (r(2) = 0.132; P = .151). CONCLUSIONS: FGF-23 levels decrease dramatically after renal transplantation. During the early PRT period, Pi rapidly decreased, suggesting that FGF-23 is cleared by the kidney, but residual FGF-23 may contribute to the PRT hypophosphatemia. FGF-23, but not PTH levels, was independently associated with PRT hypophosphatemia.
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Authors | S Y Han, E A Hwang, S B Park, H C Kim, H T Kim |
Journal | Transplantation proceedings
(Transplant Proc)
Vol. 44
Issue 3
Pg. 657-60
(Apr 2012)
ISSN: 1873-2623 [Electronic] United States |
PMID | 22483462
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- FGF23 protein, human
- Fibroblast Growth Factors
- Fibroblast Growth Factor-23
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Topics |
- Adult
- Female
- Fibroblast Growth Factor-23
- Fibroblast Growth Factors
(blood)
- Humans
- Hypophosphatemia
(blood, etiology)
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Prospective Studies
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