Abstract | BACKGROUND: AIMS: METHODS: RESULTS: ISA significantly ameliorated macroscopic damage, reduced colon weight/length ratios and the activity of MPO, depressed MDA and NO levels and iNOS activity, and enhanced GSH level, and GSH-Px and SOD activities in the colon tissues of experimental colitis in a dose-dependent manner. Moreover, the effect of ISA (200 mg/kg) was as effective as sulfasalazine (500 mg/kg). CONCLUSIONS: The findings of this study demonstrate the protective effect of ISA on experimental colitis, probably due to an antioxidant action.
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Authors | Jian-Feng Xing, Jian-Ning Sun, Jin-Yao Sun, Cui-Yu You, Kai Dong, Jun Lv, Ya-Lin Dong |
Journal | Digestive diseases and sciences
(Dig Dis Sci)
Vol. 57
Issue 8
Pg. 2045-54
(Aug 2012)
ISSN: 1573-2568 [Electronic] United States |
PMID | 22476587
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- 3,4-oxoisopropylideneshikimic acid
- Shikimic Acid
- Nitric Oxide
- Malondialdehyde
- Trinitrobenzenesulfonic Acid
- Glutathione Peroxidase
- Nitric Oxide Synthase Type II
- Nos2 protein, rat
- Superoxide Dismutase
- Glutathione
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Topics |
- Animals
- Colitis, Ulcerative
(drug therapy, pathology)
- Colon
(immunology, metabolism, pathology)
- Disease Models, Animal
- Drug Evaluation, Preclinical
- Glutathione
(metabolism)
- Glutathione Peroxidase
(metabolism)
- Male
- Malondialdehyde
(metabolism)
- Neutrophil Infiltration
- Nitric Oxide
(metabolism)
- Nitric Oxide Synthase Type II
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Shikimic Acid
(analogs & derivatives, pharmacology, therapeutic use)
- Superoxide Dismutase
(metabolism)
- Trinitrobenzenesulfonic Acid
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