Abstract | UNLABELLED: AIM: This study further evaluated the effects of morusinol, a flavonoid derived from Morus alba root bark, on platelet aggregation and thromboxane B(2) (TXB(2) formation in vitro and thrombus formation in vivo. METHODS: RESULTS:
Morusinol significantly inhibited collagen- and arachidonic acid-induced platelet aggregation and TXB(2) formation in cultured platelets in a concentration-dependent manner. Thrombus formation was reduced by 32.1, 42.0, and 99.0% for collagen-induced TXB(2) formation, and 8.0, 24.1, and 29.2% for arachadonic acid-induced TXB(2) formation, with 5, 10, and 30 µg/mL morusinol, respectively. Moreover, oral morusinol (20 mg/kg) or aspirin (20 mg/kg) for three days significantly increased the time to occlusion in vivo by 20.3±5.0 or 6.8±2.9 min, respectively, compared with the control (1% CMC, carboxymethyl cellulose). CONCLUSION:
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Authors | Jung-Jin Lee, Hyun Yang, Yeong-Min Yoo, Seong Su Hong, Dongho Lee, Hyun-Jung Lee, Hak-Ju Lee, Chang-Seon Myung, Kyung-Chul Choi, Eui-Bae Jeung |
Journal | Journal of atherosclerosis and thrombosis
(J Atheroscler Thromb)
Vol. 19
Issue 6
Pg. 516-22
( 2012)
ISSN: 1880-3873 [Electronic] Japan |
PMID | 22472211
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Flavonoids
- Plant Extracts
- morusinol
- Thromboxane B2
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Topics |
- Animals
- Arteries
(drug effects, pathology)
- Blood Platelets
(drug effects)
- Cardiovascular Diseases
(drug therapy)
- Electron Spin Resonance Spectroscopy
- Flavonoids
(chemistry, isolation & purification, pharmacology)
- Magnetic Resonance Spectroscopy
- Male
- Molecular Structure
- Morus
(chemistry)
- Plant Extracts
(pharmacology)
- Plant Roots
(chemistry)
- Platelet Activation
(drug effects)
- Platelet Aggregation
(drug effects)
- Rabbits
- Thrombosis
(drug therapy)
- Thromboxane B2
(metabolism)
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