Abstract | PURPOSE: MATERIALS AND METHODS: Subjects were 78 patients with IPF who underwent CT on two occasions with one-year interval (38 consecutive patients treated with pirfenidone and 40 age-matched control). Changes in the fibrous lesion on sequential CTs were assessed as visual score by two radiologists. We measured the volume and change per year of fibrous pattern (F-pattern) quantitatively using a computer-aided system on sequential CTs. RESULTS: The baseline vital capacity (% pred VC) was 74.0 ± 14.0% in the pirfenidone group and 74.6 ± 16.6% in controls (p=NS). Deterioration of respiratory status was defined as 10% or greater decline in % pred VC value after 12-month treatment. A significantly larger proportion of pirfenidone-treated patients showed stable respiratory status (21 of 38, 65.6%) than the control (15 of 40, 37.5%). The change in fibrous lesion was significantly smaller in the pirfenidone group than the control in both of visual score (p=0.006) and computer analysis (p<0.001). The decline in VC correlated significantly with the increase in fibrotic lesion (p<0.001). CONCLUSION:
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Authors | Tae Iwasawa, Takashi Ogura, Fumikazu Sakai, Tetsu Kanauchi, Takanobu Komagata, Tomohisa Baba, Toshiyuki Gotoh, Satoshi Morita, Takuya Yazawa, Tomio Inoue |
Journal | European journal of radiology
(Eur J Radiol)
Vol. 83
Issue 1
Pg. 32-8
(Jan 2014)
ISSN: 1872-7727 [Electronic] Ireland |
PMID | 22465123
(Publication Type: Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Pyridones
- pirfenidone
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Topics |
- Aged
- Anti-Inflammatory Agents, Non-Steroidal
(therapeutic use)
- Female
- Humans
- Idiopathic Pulmonary Fibrosis
(diagnostic imaging, drug therapy)
- Lung
(diagnostic imaging, drug effects)
- Male
- Pyridones
(therapeutic use)
- Reproducibility of Results
- Sensitivity and Specificity
- Tomography, X-Ray Computed
(methods)
- Treatment Outcome
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