[Preloading with HES 130/0.4 versus normal saline solution to prevent hypotension during spinal anaesthesia for elective caesarean section].

Abstract

OBJECTIVE:

To evaluate the efficacy of HES 130/0.4 preload compared to normal saline solution for prevention of hypotension during spinal anaesthesia for elective caesarean section.

STUDY DESIGN:

Prospective, randomized.

PATIENTS AND METHODS:

Sixty ASA I patients scheduled for elective caesarean section were randomized to receive either 1000 mL of normal saline solution preload (Group C) or 500 mL of HES 130/0.4 preload (Group V) within 15 minutes prior to spinal anaesthesia. Spinal anaesthesia techniques and ephedrine administration was standardized in both groups. The primary endpoint was the incidence of maternal hypotension before fetal extraction.

RESULTS:

The incidence of hypotension before fetal extraction was significantly lower in group V compared to group C (40% vs 66%, P=0.03). Ephedrine consumption was significantly lower in group V (7.6 ± 13 mg vs 16.4 ± 15 mg). Lowest systolic blood pressure was significantly higher in group V (96 ± 14 vs 85 ± 14 mmHg, P=0.005). Incidence of adverse maternal effects and neonatal consequences were similar in both groups.

CONCLUSION:

HES 130/0.4 preload reduced the incidence of hypotension, the duration of longest hypotension, and the need for ephedrine during spinal anaesthesia for elective caesarean section. However, the efficacy of HES 130/0.4 alone in prevention of maternal hypotension during spinal anaesthesia for caesarean section is still insufficient.

• Authors: M Bouchnak, M Magouri, S Abassi, K Khemiri, F Tlili, H Troudi, H Trabelsi, H Jabri, A Ben Mabrouk, A Abid, H Maghrebi
• Journal: Annales francaises d'anesthesie et de reanimation (Ann Fr Anesth Reanim) Vol. 31 Issue 6 Pg. 523-7 (Jun 2012) ISSN: 1769-6623 [Electronic] France
• Vernacular Title: Préremplissage par HEA 130/0,4 versus sérum salé isotonique dans la prévention de l'hypotension au cours de la rachianesthésie pour césarienne programmée.
• PMID: 22464164 (Publication Type: English Abstract, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2012 Société française d’anesthésie et de réanimation (Sfar). Published by Elsevier SAS. All rights reserved.

Chemical References

• HES 130-0.4
• Hydroxyethyl Starch Derivatives
• Plasma Substitutes
• Vasoconstrictor Agents
• Sodium Chloride
• Ephedrine

Topics

• Adult
• Anesthesia, Spinal
• Blood Pressure (physiology)
• Cesarean Section
• Ephedrine
• Female
• Humans
• Hydroxyethyl Starch Derivatives (administration & dosage, therapeutic use)
• Hypotension (prevention & control)
• Infant, Newborn
• Intraoperative Complications (prevention & control)
• Plasma Substitutes (administration & dosage, therapeutic use)
• Pregnancy
• Prospective Studies
• Sodium Chloride (administration & dosage, therapeutic use)
• Vasoconstrictor Agents