Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases.

Abstract

We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including steroid pulse therapy, resulting in significant improvement in respiratory symptoms, clinical data, and imaging. Measurement of anti-CADM-140/MDA5 antibody was useful for obtaining a definitive diagnosis of CADM in these cases.

• Authors: Yoshiro Horai, Eriko Isomoto, Tomohiro Koga, Akitomo Okada, Shin-Ya Kawashiri, Mami Tamai, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Yasuhito Hamaguchi, Manabu Fujimoto, Masataka Kuwana, Atsushi Kawakami
• Journal: Modern rheumatology (Mod Rheumatol) Vol. 23 Issue 1 Pg. 190-4 (Jan 2013) ISSN: 1439-7609 [Electronic] England
• PMID: 22460910 (Publication Type: Case Reports, Journal Article)

Chemical References

• Autoantibodies
• CADM-140 peptide, human
• Glucocorticoids
• Immunosuppressive Agents
• Intercellular Signaling Peptides and Proteins
• Peptides

Topics

• Adult
• Autoantibodies (blood)
• Dermatomyositis (complications, diagnosis, drug therapy)
• Drug Therapy, Combination
• Early Diagnosis
• Female
• Glucocorticoids (administration & dosage, therapeutic use)
• Humans
• Immunosuppressive Agents (therapeutic use)
• Intercellular Signaling Peptides and Proteins
• Lung Diseases, Interstitial (complications, diagnosis, drug therapy)
• Middle Aged
• Muscle Weakness
• Peptides (immunology)
• Prognosis
• Pulse Therapy, Drug
• Radiography, Thoracic
• Recovery of Function
• Remission Induction
• Tomography, X-Ray Computed
• Treatment Outcome