Relationship between acute chest syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study.

Abstract

The present study evaluated the relationship between acute chest syndrome (ACS) and autonomic nervous system (ANS) activity in patients with hemoglobin SS disease (Hb SS). Nine patients had suffered ACS were matched by age and gender to patients who had not suffered ACS and ANS activity, pulmonary function and history of painful crisis were compared. Correlations between number of episodes of ACS suffered and these variables were determined. The results demonstrated that 1) patients with a history of ACS ever had lower parasympathetic nervous system (PNS) activity and lower global ANS activity than patients with no ACS ever (p < 0.05), 2) the number of ACS episodes ever negatively correlated (p < 0.05) with PNS activity and global ANS activity and 3) There were no significant associations between lung function or a history of painful crisis in these patients. In conclusion, a history of ACS was associated with ANS dysfunction in adults with Hb SS disease.

• Authors: Jennifer M Knight-Madden, Philippe Connes, Andre Bowers, Danitza Nebor, Marie-Dominique Hardy-Dessources, Marc Romana, Harvey Reid, Aurélien P Pichon, Jean-Claude Barthélémy, Vanessa B Cumming, Jacques Elion, Marvin Reid
• Journal: Clinical hemorheology and microcirculation (Clin Hemorheol Microcirc) Vol. 53 Issue 3 Pg. 231-8 (Jan 01 2013) ISSN: 1875-8622 [Electronic] Netherlands
• PMID: 22460267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Acute Chest Syndrome (physiopathology)
• Adult
• Anemia, Sickle Cell (complications, physiopathology)
• Autonomic Nervous System (physiopathology)
• Case-Control Studies
• Female
• Heart Rate (physiology)
• Humans
• Male
• Parasympathetic Nervous System (physiopathology)
• Vagus Nerve (physiopathology)