Abstract | UNLABELLED: OBJECTIVES: PATIENTS AND METHODS: The study involved 29 patients with chronic decompensated heart failure (New York Heart Association class III/IV; mean age 77.4 ± 13.3 years). Dopamine was administered intravenously in doses varying from 1 to 5 μg/kg/min. Measurements of TSH, free triiodothyronine (FT3), free thyroxine (FT4), and ACTH were taken directly before dopamine infusion, after 12 hours of continuous infusion, and 12 hours after the 72-hour infusion was completed. RESULTS: Serum FT3 levels were significantly higher before dopamine infusion than at 12 hours post infusion (5.12 ± 1.16 vs. 4.27 ± 0.89 pmol/l, P < 0.005). Serum FT4 levels before the infusion were significantly higher than after 12 hours of continuous infusion as well as after 12 hours post infusion (18.79 ± 5.33 vs. 17.06 ± 4.61 pmol/l, P < 0.05; 18.79 ± 5.33 vs. 16.26 ± 4.53 pmol/l, P < 0.05, respectively). There were no statistically significant differences between serum TSH and ACTH levels or in creatinine clearance before, during, and 12 hours post infusion. CONCLUSIONS:
Intravenous infusion of dopamine may downregulate endocrine thyroid function; however, it has no significant effect on the pituitary gland-derived TSH and ACTH. There was no significant nephroprotective effect of low-dose dopamine infusion in patients with chronic decompensated chronic heart failure.
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Authors | Małgorzata Kobusiak-Prokopowicz, Krzysztof Sciborski, Andrzej Mysiak |
Journal | Polskie Archiwum Medycyny Wewnetrznej
(Pol Arch Med Wewn)
Vol. 122
Issue 3
Pg. 82-8
( 2012)
Poland |
PMID | 22460040
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Triiodothyronine
- Adrenocorticotropic Hormone
- Thyrotropin
- Thyroxine
- Dopamine
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Topics |
- Adrenocorticotropic Hormone
(blood)
- Aged
- Aged, 80 and over
- Dopamine
(administration & dosage)
- Female
- Heart Failure
(complications, drug therapy)
- Humans
- Infusions, Intravenous
- Kidney
(drug effects, physiopathology)
- Kidney Diseases
(etiology, prevention & control)
- Male
- Middle Aged
- Pituitary Gland
(drug effects)
- Thyroid Gland
(drug effects)
- Thyrotropin
(blood)
- Thyroxine
(blood)
- Triiodothyronine
(blood)
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