HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Analysis of early biochemical markers and regulation by tin protoporphyrin IX in a model of spontaneous osteoarthritis.

Abstract
Age-related changes in joint tissues lead to osteoarthritis (OA). Detection of early changes in OA patients may help to initiate treatments before the establishment of irreversible joint destruction. STR/ort mice develop with age a severe degenerative joint disease that resembles human OA thus allowing the investigation of biochemical markers as well as new treatments in an accelerated time frame. We have analyzed the changes in serum levels of different mediators during the early phases of idiopathic OA in STR/ort mice. Serum levels of matrix metalloproteinase-3 (MMP-3) but not those of tumor necrosis factor-α, interleukin(IL)-1β, IL-17 or prostaglandin E(2) correlated with histopathological changes in knees of STR/ort mice at 9 weeks. Treatment of animals with tin protoporphyrin IX (SnPP, 12 mg/kg/dayi.p.) for 4 weeks significantly reduced the progression of OA. Our data suggest that MMP-3 is a sensitive biomarker to detect early OA alterations and that SnPP could be a protective agent in OA.
AuthorsAitana Braza-Boïls, Maria Luisa Ferrándiz, María Carmen Terencio, María José Alcaraz
JournalExperimental gerontology (Exp Gerontol) Vol. 47 Issue 5 Pg. 406-9 (May 2012) ISSN: 1873-6815 [Electronic] England
PMID22459696 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.
Chemical References
  • Biomarkers
  • Enzyme Inhibitors
  • Inflammation Mediators
  • Metalloporphyrins
  • Protoporphyrins
  • tin protoporphyrin IX
  • Heme Oxygenase (Decyclizing)
  • Matrix Metalloproteinase 3
Topics
  • Animals
  • Arthritis, Experimental (blood, diagnosis, pathology, prevention & control)
  • Biomarkers (blood)
  • Clinical Enzyme Tests (methods)
  • Disease Progression
  • Drug Evaluation, Preclinical (methods)
  • Early Diagnosis
  • Enzyme Inhibitors (therapeutic use)
  • Heme Oxygenase (Decyclizing) (antagonists & inhibitors)
  • Inflammation Mediators (metabolism)
  • Male
  • Matrix Metalloproteinase 3 (blood)
  • Metalloporphyrins (therapeutic use)
  • Mice
  • Mice, Inbred Strains
  • Osteoarthritis (blood, diagnosis, pathology, prevention & control)
  • Protoporphyrins (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: