Abstract | OBJECTIVES: MATERIALS AND METHODS: The drugs were injected in the anterior portion of mental nerve of 24 rats, divided into three groups: G1--4% articaine with 1:100,000 epinephrine; G2--2% lidocaine with 1:100,000 epinephrine and G3--plain 1:100,000 epinephrine solution. These solutions were injected in the right side of the rat's mandible and the left side was used as control ( 0.9% saline solution). Previously to the injections, the animals were anesthetized with thiopental and, 24 h after the injections, their jaws were removed and submitted to routine histological techniques. A histopathological analysis was performed by optical microscopy. RESULTS: An inflammatory infiltration was found around mental nerve, classified as intense for G3, moderate for G1 and light for both G2 and control groups. No injuries were found in nervous structure, despite the inflammatory reaction observed around it. CONCLUSION: The results suggest that articaine is not toxic to the nervous structure and further studies are necessary to explain the possible relation between articaine injection and paresthesia.
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Authors | Daniela Belisário Baroni, Michelle Franz-Montan, Karina Cogo, Luciana Aranha Berto, Maria Cristina Volpato, Pedro Duarte Novaes, Francisco Carlos Groppo |
Journal | Acta odontologica Scandinavica
(Acta Odontol Scand)
Vol. 71
Issue 1
Pg. 82-7
(Jan 2013)
ISSN: 1502-3850 [Electronic] England |
PMID | 22458536
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anesthetics, Local
- Lidocaine
- Carticaine
- Epinephrine
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Topics |
- Anesthetics, Local
(toxicity)
- Animals
- Carticaine
(toxicity)
- Epinephrine
(toxicity)
- Lidocaine
(toxicity)
- Male
- Mandibular Nerve
(drug effects)
- Nerve Block
(adverse effects)
- Paresthesia
(etiology)
- Rats
- Rats, Wistar
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