HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

The Alu polymorphism of angiotensin I converting enzyme (ACE) and atherosclerosis, incident chronic diseases and mortality in an elderly Chinese population.

AbstractOBJECTIVE:
We examined the contribution of ACE I/D polymorphism in a large Chinese population to four year change in ankle-brachial index (ABI), development of cardiovascular diseases and mortality in a prospective study adjusting for many confounding factors.
METHOD:
Data are drawn from a longitudinal study of 4000 community-living men and women aged 65 years and over, for which detailed information regarding lifestyle, chronic diseases, body mass index (BMI), ABI measurements and ACE polymorphisms were documented at baseline. During the fifth year of follow up, incident cardiovascular diseases, ABI, and mortality were documented, and related to ACE genotype adjusting for age, smoking, alcohol, dietary intake, physical activity, body mass index, and use of ACE inhibitors.
RESULTS:
Women with the D/D genotype had the greatest reduction in mean ABI after adjusting for confounding factors. D/D genotype was also more common among women who developed hypertension or myocardial infarction. However D/D genotype was associated with mortality only in men.
CONCLUSION:
In a Chinese elderly population, ACE polymorphism may be considered "deleterious" to longevity, the D/D genotype being associated with mortality, the atherosclerotic process, hypertension and myocardial infarction. There are gender differences in the relationship between D/D genotype and cardiovascular diseases and mortality may not be mediated by the atherosclerotic process alone.
AuthorsJ Woo, N L S Tang, J Leung, T Kwok
JournalThe journal of nutrition, health & aging (J Nutr Health Aging) Vol. 16 Issue 3 Pg. 262-8 (Mar 2012) ISSN: 1760-4788 [Electronic] France
PMID22456784 (Publication Type: Journal Article)
Chemical References
  • Angiotensin-Converting Enzyme Inhibitors
  • Peptidyl-Dipeptidase A
Topics
  • Aged
  • Angiotensin-Converting Enzyme Inhibitors
  • Ankle Brachial Index
  • Atherosclerosis (enzymology, genetics, mortality)
  • Body Mass Index
  • Cardiovascular Diseases (enzymology, genetics, mortality)
  • China (epidemiology)
  • Chronic Disease
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Hypertension (enzymology, genetics, mortality)
  • Incidence
  • Longitudinal Studies
  • Male
  • Peptidyl-Dipeptidase A (genetics)
  • Polymorphism, Genetic
  • Prospective Studies
  • Risk Factors
  • Sex Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: