Abstract | BACKGROUND: METHODS: This was a population-based cohort study of patients who underwent gastrectomy for peptic ulcer disease between 1964 and 2008 in Sweden. Follow-up data for cancer was obtained from the Swedish Cancer Register. Relative risk was calculated as standardised incidence ratios (SIRs) with 95% confidence intervals (CIs). RESULTS: The gastrectomy cohort comprises 19 767 patients, contributing 348 231 person-years at risk. The observed number of patients with laryngeal (n=56) and pharyngeal cancer (n=28) was two-fold higher than the expected (SIR: 2.0, 95% CI: 1.5-2.6 and SIR: 2.4, 95% CI: 1.6-3.5, respectively). After exclusion of 5536 cohort members with tobacco- or alcohol-related disease, the point SIRs remained increased (SIR: 1.6, 95% CI: 1.1-2.2 and SIR: 1.7, 95% CI: 0.9-2.8, respectively). The SIRs of laryngeal and pharyngeal cancer increased with time after gastrectomy (P for trend <0.0001), and were particularly increased 30 years after gastrectomy (SIR: 4.8, 95% CI: 2.1-9.5 and SIR: 10.2, 95% CI: 3.7-22.3, respectively). CONCLUSION:
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Authors | J Lagergren, A Lindam |
Journal | British journal of cancer
(Br J Cancer)
Vol. 106
Issue 7
Pg. 1342-5
(Mar 27 2012)
ISSN: 1532-1827 [Electronic] England |
PMID | 22453126
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Cohort Studies
- Female
- Gastrectomy
(adverse effects)
- Humans
- Laryngeal Neoplasms
(epidemiology)
- Male
- Middle Aged
- Peptic Ulcer
(surgery)
- Pharyngeal Neoplasms
(epidemiology)
- Risk Assessment
- Sweden
(epidemiology)
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