Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study.

Abstract

We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-aspartate, 10 and 8 days for Mg L-glutamate and Mg D-aspartate, respectively, and 11 days for Mg DL-aspartate and Mg DL-glutamate. These findings attest to better bioavailability of Mg complex with L-stereoisomer of aspartate in comparison with DL and D-stereoisomers and stereoisomers of Mg glutamate.

• Authors: A A Spasov, A A Ozerov, I N Iezhitsa, M V Kharitonova, M S Kravchenko, A A Zheltova
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 151 Issue 3 Pg. 333-5 (Jul 2011) ISSN: 1573-8221 [Electronic] United States
• PMID: 22451880 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Magnesium Compounds
• Aspartic Acid
• Furosemide
• Magnesium

Topics

• Animals
• Aspartic Acid (administration & dosage, pharmacology)
• Furosemide (toxicity)
• Magnesium (administration & dosage, pharmacology)
• Magnesium Compounds (administration & dosage, pharmacology)
• Magnesium Deficiency (chemically induced, drug therapy)
• Male
• Rats
• Stereoisomerism