Multidisciplinary treatment approach in Treacher Collins syndrome.

Abstract

Treacher Collins syndrome (TCS) is a common genetic disorder with high penetrance and phenotypic variability. First and second branchial arches are affected in TCS, resulting in craniofacial and intraoral anomalies such as: severe convex facial profile; mid-face hypoplasia; microtia; eyelid colobomas; mandibular retrognathism; cleft palate; dental hypoplasia; heterotopic teeth; maxillary transverse hypoplasia; anterior open bite; and Angle Class II molar relationship. A high incidence of caries is also a typical finding in TCS patients. Nonetheless, even simple dental restorative procedures can be challenging in this patient population due to other associated medical conditions, such as: congenital heart defects; decreased oropharyngeal airways; hearing loss; and anxiety toward treatment. These patients often require a multidisciplinary treatment approach, including: audiology; speech and language pathology; otorhinolaryngology; general dentistry; orthodontics; oral and maxillofacial surgery; and plastic and reconstructive surgeries to improve facial appearance. This paper's purpose was to present a current understanding of Treacher Collins syndrome etiology, phenotype, and current treatment approaches.

• Authors: Joseph B Hylton, Vladimir Leon-Salazar, Gary C Anderson, Nanci L O De Felippe
• Journal: Journal of dentistry for children (Chicago, Ill.) (J Dent Child (Chic)) Vol. 79 Issue 1 Pg. 15-21 ( 2012) ISSN: 1935-5068 [Electronic] United States
• PMID: 22449504 (Publication Type: Journal Article, Review)

Topics

• Child
• Combined Modality Therapy
• Dental Care
• Humans
• Mandibulofacial Dysostosis (complications, therapy)
• Phenotype