Abstract | PURPOSE: METHODS: A total of 33 subjects eligible for inclusion were selected from 105 patients clinically diagnosed with optic nerve contusion. These patients were subsequently divided into the control group (n=16) and the intervention group (n=17). In the control group, the participants received therapy consisting of glucocorticoids, mannitol, vasodilators and vitamin B. The patients in the intervention group additionally received anisodine in combination with citicoline. The visual acuity was graded on a scale from 0 to 8. RESULTS: Prior to treatment, the 25th, 50th and 75th percentiles of visual acuity grade were 3, 4 and 6.75 for the controls, and 3, 4 and 6.5 for the patients in the intervention group. (P=0.97). After treatment, the 25th, 50th and 75th percentiles of visual acuity grade were 4, 6 and 7.75 in the control group, and 7, 7 and 8 in the intervention group. (P=0.046). A significant difference was observed in both control (P=0.005) and intervention groups (P=0.001) when comparing presenting visual acuity before and after treatment. CONCLUSION:
|
Authors | Wenhua Wang, Yan Huang, Jianli Zhang, Jiahai Jiang, Jinxiu Huang |
Journal | Eye science
(Eye Sci)
Vol. 27
Issue 1
Pg. 37-40
(Mar 2012)
ISSN: 1000-4432 [Print] China |
PMID | 22447551
(Publication Type: Journal Article)
|
Chemical References |
- Glucocorticoids
- Scopolamine Derivatives
- Mannitol
- Cytidine Diphosphate Choline
- anisodine
|
Topics |
- Contusions
(drug therapy)
- Cytidine Diphosphate Choline
(therapeutic use)
- Drug Therapy, Combination
(methods)
- Female
- Glucocorticoids
(therapeutic use)
- Humans
- Male
- Mannitol
(therapeutic use)
- Middle Aged
- Optic Nerve Injuries
(drug therapy)
- Scopolamine Derivatives
(therapeutic use)
- Treatment Outcome
- Visual Acuity
(drug effects, physiology)
|