Abstract | OBJECTIVE: METHODS: Thirty-two healthy male C57B6J mice were randomly divided into four groups: CIH (12 weeks of CIH), ARB (CIH+Telmisartan), air control (room air delivery), and blank control (no treatment). AngII, p47( phox), and 8-OHdG/8-OHG were detected in mouse cardiocytes by immunohistochemistry. MDA was measured with the thiobarbituric acid method. MEASUREMENTS AND RESULTS: The highest AngII levels occur in the ARB treatment group (P < 0.05), followed by the CIH group (which was higher than the two control groups; P = 0.000). The levels of p47( phox) were statistically higher in the CIH group than in the other groups (P = 0.000) and lower in the ARB group (but still higher than in the two control groups, P = 0.000). The levels of 8-OHdG/8-OHG were the highest in the CIH group (P < 0.05), followed by the ARB group (which was higher than the two control groups, P = 0.000). The levels of MDA in the myocardial homogenate of mice were the highest in the CIH group (P = 0.000). CONCLUSIONS: Based on the above results, it can be concluded that Telmisartan may protect mouse cardiocytes from oxidative stress damage due to CIH.
|
Authors | Wan-Yu Wang, Wan-Yu Wan, Yi-Ming Zeng, Xiao-Yang Chen, Yi-Xiang Zhang |
Journal | Sleep & breathing = Schlaf & Atmung
(Sleep Breath)
Vol. 17
Issue 1
Pg. 181-7
(Mar 2013)
ISSN: 1522-1709 [Electronic] Germany |
PMID | 22447170
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Benzimidazoles
- Benzoates
- Biomarkers
- NADPH Oxidases
- Telmisartan
|
Topics |
- Administration, Oral
- Angiotensin II Type 1 Receptor Blockers
(pharmacology)
- Animals
- Benzimidazoles
(pharmacology)
- Benzoates
(pharmacology)
- Biomarkers
(analysis)
- Chronic Disease
- Disease Models, Animal
- Hypoxia
(physiopathology)
- Male
- Mice
- Mice, Inbred Strains
- Myocardium
(pathology)
- NADPH Oxidases
(physiology)
- Oxidative Stress
(drug effects, physiology)
- Reference Values
- Sleep Apnea, Obstructive
(physiopathology)
- Telmisartan
|