Abstract | BACKGROUND: METHODS: MBL genetic polymorphisms of 151 pediatric patients with infectious diseases and 105 healthy controls were detected by PCR and sequencing. Serum MBL levels of all the patients and controls were measured using a Human MBL ELISA Kit. Differences in MBL genetic polymorphisms and serum levels between patients and controls were analyzed by statistical methods. RESULTS: The frequencies of allele H/L at position -550 of the promoter and three haplotypes - HYPA, HYPB, and LYPB - were statistically different between patients and controls (p<0.05). The frequencies of genotypes 'YA' and 'XB', relevant to serum protein levels, were also significantly different between patients and controls (p<0.05). Serum MBL levels of patients with active CMV infection were significantly lower than those of controls (p<0.05). Conversely, serum MBL levels of patients with ARI and localized abscess were significantly higher than those of controls (p<0.05). CONCLUSIONS: Genetic polymorphisms attributable to mutations in the promoter and exon 1 of the MBL2 gene appear to be relatively common in pediatric patients with infectious diseases. Low serum MBL levels may play a role in the high sensitivity of pediatric CMV infections.
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Authors | Ran Tao, Chun-Zhen Hua, Ying-Zi Hu, Shi-Qiang Shang |
Journal | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
(Int J Infect Dis)
Vol. 16
Issue 5
Pg. e403-7
(May 2012)
ISSN: 1878-3511 [Electronic] Canada |
PMID | 22444663
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- MBL2 protein, human
- Mannose-Binding Lectin
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Topics |
- Abscess
(blood, genetics)
- Acute Disease
- Asian People
- Case-Control Studies
- Child
- Child, Preschool
- Cytomegalovirus Infections
(blood, genetics)
- Exons
- Female
- Gene Frequency
- Haplotypes
- Humans
- Infant
- Male
- Mannose-Binding Lectin
(blood, genetics)
- Otitis Media
(blood, genetics)
- Polymorphism, Single Nucleotide
- Promoter Regions, Genetic
- Recurrence
- Respiratory Tract Infections
(blood, genetics)
- Sequence Analysis, DNA
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