Decline in circulating insulin-like growth factors and mortality in older adults: cardiovascular health study all-stars study.

Abstract

BACKGROUND:

The association between changes in IGF-I and IGF binding protein (IGFBP) levels and mortality in older adults is unknown.

STUDY DESIGN:

Participants were 997 persons 77 to 100 yr old enrolled in the Cardiovascular Health Study All Stars Study. Plasma levels of IGF-I, IGFBP-1, and IGFBP-3 were assessed at two study examinations (1996-1997 and 2005-2006). Mortality was assessed between 2006 and 2010.

RESULTS:

Cumulative mortality (CM) was similar among individuals who had at least 10% decreases over time in IGF-I levels (CM = 29.6%), individuals who had at least 10% increases over time in IGF-I levels (CM = 24.7%), and individuals who had IGF-I levels remaining within ±10% over time (CM = 23.5%). Adjusted for age, sex, race, diabetes, body mass index, creatinine, albumin, and C-reactive protein, decreasing IGF-I level had no significant association with overall cancer mortality or noncancer mortality. Levels of IGFBP-1 increased markedly over time by 38% (median). Individuals with the largest increases in IGFBP-1 level over time had significantly increased risk of mortality. The adjusted hazard ratio per sd of IGFBP-1 change was 1.40 for overall cancer mortality (95% confidence interval = 1.10, 1.77; P = 0.01) and 1.14 for noncancer mortality (95% confidence interval = 1.02, 1.27; P = 0.02). Changes in IGFBP-3 levels were not significantly associated with mortality.

CONCLUSION:

Among older adults, decreasing IGF-I level over time does not predict subsequent all-cause mortality, whereas increasing IGFBP-1 predicts increased risk of mortality.

• Authors: Robert C Kaplan, Petra Bùzková, Anne R Cappola, Howard D Strickler, Aileen P McGinn, Laina D Mercer, Alice M Arnold, Michael N Pollak, Anne B Newman
• Journal: The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 97 Issue 6 Pg. 1970-6 (Jun 2012) ISSN: 1945-7197 [Electronic] United States
• PMID: 22442270 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• IGFBP1 protein, human
• IGFBP3 protein, human
• Insulin-Like Growth Factor Binding Protein 1
• Insulin-Like Growth Factor Binding Protein 3
• Insulin-Like Growth Factor I

Topics

• Aged
• Aged, 80 and over
• Black People (statistics & numerical data)
• Cardiovascular Diseases (blood, mortality)
• Female
• Follow-Up Studies
• Humans
• Insulin-Like Growth Factor Binding Protein 1 (blood)
• Insulin-Like Growth Factor Binding Protein 3 (blood)
• Insulin-Like Growth Factor I (metabolism)
• Longitudinal Studies
• Male
• Mortality (trends)
• Predictive Value of Tests
• Risk Factors
• White People (statistics & numerical data)